Frunevetmab side effects

solensia works differently from current treatment options by targeting nerve growth factor (ngf), a key player in osteoarthritis (oa) pain. 1,2 it functions like naturally occurring antibodies,.Zoetis Inc., an animal health company announced that Solensia, its treatment of osteoarthritis, has been granted marketing authorization from the European Commission. throttling exception dynamodb The most common side effects seen in cats include vomiting, diarrhea, injection site pain, scabbing on the head and neck, dermatitis and pruritus (itchy skin). [2] Frunevetmab is a cat-specific monoclonal antibody (a type of protein) designed to recognize and attach to a protein called nerve growth factor (NGF) that is involved in the ...The most common side effects in clinical studies were erythematous rashes. [6] A boxed warning has been added to the safety label to describe an increase rate of death from cancer when three or more tubes are used. [7] Regranex should be used with caution in patients with known malignancy. [1] See also [ edit] Nepidermin References [ edit]Jan 20, 2023 · Some potential side effects include: fever, chills, and other flu-like symptoms. hot flashes. joint pain. leg cramps. sweating. swelling in the hands or feet. infection. Studies have also linked ... heggerty scope and sequence pdf In human clinical trials, the placebo effect does not diminish over time, 42 and in the pilot proof of concept study with frunevetmab, the placebo rate was maintained out to the end of the study (63 days after treatment). 25 A combined analysis of the data from all the frunevetmab trials would provide a better estimate of the clinical utility ...flushed, dry skin. fruit-like breath odor. increased hunger. increased thirst. increased urination. lack or loss of strength. nausea. rash with flat lesions or small raised lesions on the skin. redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid. south park jimmy x male reader Solensia should not be administered to cats with known hypersensitivity to frunevetmab. The most common adverse events reported in a clinical study were vomiting and injection site pain. IMPORTANT SAFETY INFORMATION: See full Prescribing Information. For use in cats only. Solensia should not be administered to cats with known hypersensitivity to frunevetmab. The most common adverse events reported in a clinical study were vomiting and injection site pain. REFERENCES. Gruen ME, Myers JAE and Lascelles BDX (2021) Efficacy and Safety of an Anti-nerve Growth Factor Antibody (Frunevetmab) for the Treatment of ...Focal skin reactions (e.g. pruritus, dermatitis and alopecia) occurred commonly in studies. The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction (s)) - common (more than 1 but less than 10 animals in 100 animals treated) shovelhead frame with title for saleLog In My Account ey. ey; vvJan 13, 2022 · Solensia was found to be well-tolerated: the most common side effects were vomiting and injection site pain. 6 ... Solensia should not be administered to cats with known allergy to frunevetmab ... Frunevetmab is a felinized immunoglobulin G monoclonal antibody (mAb), a murine antibody in which all regions of the mouse antibody are replaced with feline … parkdale toronto crime Frunevetmab, sold under the brand name Solensia, is a medication used to treat pain associated with osteoarthritis in cats. The most common side effects seen in cats include vomiting, …Nov 1, 2021 · Frunevetmab, a felinized antinerve growth factor monoclonal antibody, effectively decreases osteoarthritis (OA) pain in cats. Objective To evaluate the efficacy of frunevetmab given at monthly intervals in a randomized, placebo-controlled, parallel-group, double-blind superiority study. Animals 2021/07/20 ... Secondly, it has a great adverse effect profile with no impact on the ... Frunevetmab (Solensia) was tested in client-owned cats versus ...RARE side effects If experienced, these tend to have a Severe expression i ; low levels of white blood cells ; increased eosinophils in the blood ; hemorrhage from the conjunctiva of the eye ;Frunevetmab is a felinized monoclonal antibody that binds to nerve growth factor (NGF) and provides relief from pain by blocking the receptor-mediated signaling cascade induced by NGF. Results from three studies were combined to provide an overview of frunevetmab pharmacokinetics (PK) and immunogenicity.Frunevetmab, sold under the brand name Solensia, is a medication used to treat pain associated with osteoarthritis in cats. The most common side effects seen in cats include vomiting, diarrhea, injection site pain, scabbing on the head and neck, dermatitis and pruritus (itchy skin). roblox bypassed audios april 2022 Librela (bedinvetmab) and Solensia (frunevetmab) work by targeting Nerve Growth Factors (NGF), which have key involvement in OA pain 2. As monoclonal antibodies, they are eliminated by the body in the same way as naturally occurring proteins, with minimal involvement of the liver or the kidney 4. Undertreated OA pain can limit quality of lifesolensia works differently from current treatment options by targeting nerve growth factor (ngf), a key player in osteoarthritis (oa) pain. 1,2 it functions like naturally occurring antibodies,.Zoetis Inc., an animal health company announced that Solensia, its treatment of osteoarthritis, has been granted marketing authorization from the European Commission. small motor sailers Allergic reactions, including anaphylaxis, could potentially occur with self-injection. Solensia should not be used in breeding cats or in pregnant or lactating queens. Solensia should not be administered to cats with known allergy to frunevetmab. The most common adverse events reported in a clinical study were vomiting and injection site pain. john deere tractors for sale northern ireland (frunevetmab) in the treatment of DJD-associated pain. 25,26 Despite considerable advances over the last 15 years in our understanding of how to measure chronic pain in cats,27 a profound placebo effect (up to 80%) is described in clinical chronic pain trials using subjective owner assessment that trends higher with longer duration studies.28with minimal adverse effects that most animals tolerate well.2,3 It has become more accepted for pain relief in veterinary medicine.May 28, 2021 · Recent work has shown promise for a feline-specific anti-nerve growth factor monoclonal antibody (frunevetmab) to deliver safe and effective pain management. Our objectives were to evaluate the efficacy and safety of frunevetmab administered twice using two administration routes (subcutaneous and intravenous) compared to placebo. sun conjunct north node 12th house Frunevetmab, the active ingredient in Solensia, is a cat-specific monoclonal antibody, a type of protein. It is designed to recognize and attach to a protein called nerve growth factor or NGF that ...with minimal adverse effects that most animals tolerate well.2,3 It has become more accepted for pain relief in veterinary medicine. bypassed roblox clothing groups The most common side effects with Solensia (which may affect up to 1 in 10 animals) are skin reactions (itching, skin inflammation and hair loss). Solensia should not be used in cats under 1 year of age or weighing less than 2.5 kg. It is al so not for cats intended for breeding or cats that are pregnant or nursing kittens .2021/07/20 ... Secondly, it has a great adverse effect profile with no impact on the ... Frunevetmab (Solensia) was tested in client-owned cats versus ...Weakness Weight loss Fever Frequent infections Blood in urine or stool Shortness of breath Feeling very tired Bruising or bleeding more easily Your doctor will do blood tests to check your blood cell counts Before treatment with LYNPARZA Every month during treatment with LYNPARZA Weekly, if you have low blood cell counts that last a long time.Frunevetmab is a monoclonal antibody designed specifically for cats. It neutralizes Nerve Growth Factor (NGF), a key player involved in osteoarthritis in cats, and in doing so reduces pain. During the pivotal clinical trial, Solensia ® demonstrated a positive profile, and a total of 76% of cat owners reported sustained improvement in signs of ...The most common side effects with Solensia (which may affect up to 1 in 10 animals) are skin reactions (itching, skin inflammation and hair loss). Solensia should not be used in cats under 1 year of age or weighing less than 2.5 kg. It is al so not for cats intended for breeding or cats that are pregnant or nursing kittens .The side effects of NGF inhibitors have been known for over a decade. The FDA slowed the development of NGF inhibitors in 2010 because of concerns they make … fart porno Frunevetmab, sold under the brand name Solensia, is a medication used to treat pain associated with osteoarthritis in cats. The most common side effects seen in cats include vomiting, diarrhea, injection site pain, scabbing on the head and neck, dermatitis and pruritus (itchy skin). triplet alphas gifted luna chapter 8 Frunevetmab is a felinized monoclonal antibody that binds to nerve growth factor (NGF) and provides relief from pain by blocking the receptor-mediated signaling cascade induced by NGF. Results from three studies were combined to provide an overview of frunevetmab pharmacokinetics (PK) and immunogenicity.In a press release announcing the approval of Solensia for cats, the FDA makes no mention of RPOA in its list of side effects, which includes vomiting, diarrhea, injection site pain, scabbing, dermatitis and itchy skin. The release said side effects were mild and did not require ending treatment during observational animal studies.2022/01/17 ... “The FDA encourages cat owners to work with their veterinary team to report any adverse events or side effects potentially related to the use of ... sendero verde photos Background: Frunevetmab, a felinized antinerve growth factor monoclonal antibody, effectively decreases osteoarthritis (OA) pain in cats. Objective: To evaluate the efficacy of frunevetmab …2021/09/04 ... No adverse effects were reported after FMT. ... was to evaluate the effect of frunevetmab on the functional immune response in naïve cats. the hottest smallest nude OA pain can also affect sleep, cognitive function, affect (emotion) and social relationships." "NGF is one of the key factors mediating pain, inducing the release of both pro-inflammatory mediators...When frunevetmab binds to NGF, it prevents the pain signal from reaching the brain, the FDA explained. ... The most common side effects seen in cats treated with Solensia included vomiting ...Frunevetmab, sold under the brand name Solensia, is a medication used to treat pain associated with osteoarthritis in cats. The most common side effects seen in cats include vomiting, diarrhea, injection site pain, scabbing on the head and neck, dermatitis and pruritus .Neither is known for side effects aside from potential irritation of injection site (confirm all of this info with your vet of course). Solensia typically takes at least 6 days to start working, I will say with the combination I have continued to notice a HUGE difference, I'm talking no symptoms except some slight stiffness when walking. making the cut season 2 winner controversy Recent work has shown promise for a feline-specific anti-nerve growth factor monoclonal antibody (frunevetmab) to deliver safe and effective pain management. Our objectives were to evaluate the efficacy and safety of frunevetmab administered twice using two administration routes (subcutaneous and intravenous) compared to placebo.Efficacy and Safety of an Anti-nerve Growth Factor Antibody (Frunevetmab) for the Treatment of Degenerative Joint Disease-Associated Chronic Pain in Cats: A Multisite Pilot Field Study . doi: 10.3389/fvets.2021.610028. eCollection 2021. Authors Margaret E Gruen 1 2 3 , Jamie A E Myers 4 , B Duncan X Lascelles 1 3 5 6 AffiliationsThe most common side effects with Solensia (which may affect up to 1 in 10 animals) are skin reactions (itching, skin inflammation and hair loss). Solensia should not be used in cats under 1 year of age or weighing less than 2.5 kg. It is al so not for cats intended for breeding or cats that are pregnant or nursing kittens . what balun do i need for a dipole Side Effects of Creatine. When consumed in this manner, Creatine is thought to be safe for the vast majority of people. There have been reports of it being effective when administered in doses as high as 25 grams per day for as long as 14 days. It has also been used successfully at lower doses, up to 4-5 grams daily for up to 18 months.Solensia is a once-monthly, injectable monoclonal antibody therapy for the control of feline osteoarthritis (OA) pain. Controls the pain of OA in cats, helping to improve their mobility, comfort and well-being 1. 77% of cat owners reported improvement in signs of pain when their cats were treated monthly with Solensia in a 3-month study †. my ex blocked me and then unblocked me Solensia is an immunological medicinal product containing frunevetmab (ATCvet code QN02BG90) as active substance, which is a felinised monoclonal antibody (mAb) targeting nerve growth factor (NGF). The inhibition of NGF-mediated cell signalling was demonstrated to provide relief from pain associated with osteoarthritis.Jan 13, 2022 · Solensia was found to be well-tolerated: the most common side effects were vomiting and injection site pain. 6 “While feline osteoarthritis isn’t curable, the pain from osteoarthritis can be effectively managed 1,” said Margaret E. Gruen, DVM, MVPH, PhD, DACVB, Assistant Professor of Behavioral Medicine at North Carolina State University ... May 28, 2021 · Recent work has shown promise for a feline-specific anti-nerve growth factor monoclonal antibody (frunevetmab) to deliver safe and effective pain management. Our objectives were to evaluate the efficacy and safety of frunevetmab administered twice using two administration routes (subcutaneous and intravenous) compared to placebo. coin tales facebook 2021/04/13 ... Zoetis says Librela (bedinvetmab) and Solensia (frunevetmab) work differently from NSAIDs, the current standard of care, by specifically ...In human clinical trials, the placebo effect does not diminish over time, 42 and in the pilot proof of concept study with frunevetmab, the placebo rate was maintained out to the end of the study (63 days after treatment). 25 A combined analysis of the data from all the frunevetmab trials would provide a better estimate of the clinical utility ...Overall, frunevetmab administration resulted in a very low incidence of treatment-emergent immunogenicity with no safety findings and minimal effect on drug exposure and efficacy. View Show abstractSalt Intake Side Effects: आज के समय में किडनी स्टोन (kidney stone) की समस्या बढ़ती उम्र के लोगों को ही नहीं, बल्कि युवाओं को तेजी से अपनी चपेट में ले रही है ... beach bar for sale vietnam Frunevetmab, sold under the brand name Solensia, is a medication used to treat pain associated with osteoarthritis in cats. The most common side effects seen in cats include vomiting, diarrhea, injection site pain, scabbing on the head and neck, dermatitis and pruritus .Focal skin reactions (e.g. pruritus, dermatitis and alopecia) occurred commonly in studies. The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction (s)) - common (more than 1 but less than 10 animals in 100 animals treated) red and white wedding dresses davidpercent27s bridal Solensia should not be administered to cats with known hypersensitivity to frunevetmab. The most common adverse events reported in a clinical study were vomiting and injection site pain. REFERENCES. Gruen ME, Myers JAE and Lascelles BDX (2021) Efficacy and Safety of an Anti-nerve Growth Factor Antibody (Frunevetmab) for the Treatment of ...The most common side effects with Solensia (which may affect up to 1 in 10 animals) are skin reactions (itching, skin inflammation and hair loss). Solensia should not be used in cats under 1 year of age or weighing less than 2.5 kg. It is al so not for cats intended for breeding or cats that are pregnant or nursing kittens . houses to rent helston Officials with the FDA have approved frunevetmab injection (Zoetis; Solensia), the first treatment for the control of pain associated with osteoarthritis in cats and the first …Allergic reactions, including anaphylaxis, could potentially occur with self-injection. Solensia should not be used in breeding cats or in pregnant or lactating queens. Solensia should not be administered to cats with known allergy to frunevetmab. The most common adverse events reported in a clinical study were vomiting and injection site pain.Serious side effects of Fentanyl. Along with its needed effects, fentanyl may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking fentanyl: More common. Black, tarry stools ...The Chicxulub crater (IPA: [tʃikʃuˈlub] ()) is an impact crater buried underneath the Yucatán Peninsula in Mexico. Its center is offshore near the community of Chicxulub, after which it is named.It was formed slightly over 66 million years ago when a large asteroid, about ten kilometers (six miles) in diameter, struck Earth.The crater is estimated to be 180 kilometers (110 miles) in ... auto trader alberta2021/05/28 ... Conclusions and Clinical Relevance: Treatment with frunevetmab ... Three cats were withdrawn due to adverse dermatological effects in the ...You may report side effects to Health Canada at 1-866-234-2345. Precautions . Before using cefotaxime, tell your doctor or pharmacist if you are allergic to it; ...Side effects. NSAIDs are the most common treatment, but there are: ... Frunevetmab. THE FIRST AND ONLY MONTHLY INJECTABLE ANTIBODY. hsk Solensia is a once-monthly, injectable monoclonal antibody therapy for the control of feline osteoarthritis (OA) pain. Controls the pain of OA in cats, helping to improve their mobility, comfort and well-being 1. 77% of cat owners reported improvement in signs of pain when their cats were treated monthly with Solensia in a 3-month study †.flushed, dry skin. fruit-like breath odor. increased hunger. increased thirst. increased urination. lack or loss of strength. nausea. rash with flat lesions or small raised lesions on the skin. redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid.Frunevetmab, sold under the brand name Solensia, is a medication used to treat pain associated with osteoarthritis in cats. The most common side effects seen in cats include vomiting, diarrhea, injection site pain, scabbing on the head and neck, dermatitis and pruritus (itchy skin). pehu 2022/01/13 ... The most common adverse effects seen in cats treated with frunevetmab injection included vomiting, diarrhea, injection site pain, ...In a press release announcing the approval of Solensia for cats, the FDA makes no mention of RPOA in its list of side effects, which includes vomiting, diarrhea, injection site. 2x 1ml vials. Indication. Solensia is a once-a-month subcutaneous injection which is long-acting medication for cats with osteoarthritis pain. Contraindications.Nov 1, 2021 · Frunevetmab, a felinized antinerve growth factor monoclonal antibody, effectively decreases osteoarthritis (OA) pain in cats. Objective To evaluate the efficacy of frunevetmab given at monthly intervals in a randomized, placebo-controlled, parallel-group, double-blind superiority study. Animals thirteen mega link Frunevetmab is a monoclonal antibody designed specifically for cats. It neutralizes Nerve Growth Factor (NGF), a key player involved in osteoarthritis in cats, and in doing so reduces pain. During the pivotal clinical trial, Solensia ® demonstrated a positive profile, and a total of 76% of cat owners reported sustained improvement in signs of ...frunevetmab 2. STATEMENT OF ACTIVE SUBSTANCES Each vial of 1 ml contains 7 mg frunevetmab 3. PHARMACEUTICAL FORM ... If you notice any side effects, even those not already listed in this package leaflet or ... demonstrated to have a favourable effect on the reduction of pain assessed by CSOM (Client-Specific Outcome Measures). CSOM is an ...In a press release announcing the approval of Solensia for cats, the FDA makes no mention of RPOA in its list of side effects, which includes vomiting, diarrhea, injection site pain, scabbing, dermatitis and itchy skin. The release said side effects were mild and did not require ending treatment during observational animal studies.The most common side effects with Solensia (which may affect up to 1 in 10 animals) are skin reactions (itching, skin inflammation and hair loss). Solensia should not be used in cats under 1 year of age or weighing less than 2.5 kg. It is al so not for cats intended for breeding or cats that are pregnant or nursing kittens . haikyuu x reader you get hurt during an argument (frunevetmab) in the treatment of DJD-associated pain. 25,26 Despite considerable advances over the last 15 years in our understanding of how to measure chronic pain in cats,27 a profound placebo effect (up to 80%) is described in clinical chronic pain trials using subjective owner assessment that trends higher with longer duration studies.28The most common side effects seen in cats include vomiting, diarrhea, injection site pain, scabbing on the head and neck, dermatitis and pruritus (itchy ...The active ingredient in Solensia is frunevetmab, a synthetic, cat-specific, monoclonal antibody (a type of protein) that recognizes and attaches to nerve growth factor (NGF), another protein which is involved in the regulation of pain. ... Side effects in the treatment group were relatively mild and did not require cessation of treatment ...Frunevetmab, sold under the brand name Solensia, is a medication used to treat pain associated with osteoarthritis in cats. The most common side effects seen in cats include vomiting, diarrhea, injection site pain, scabbing on the head and neck, dermatitis and pruritus . jenny doan weight loss surgery The root bark is used to make medicine. People use Jamaican dogwood for anxiety, sleep problems, nerve pain, migraine, and other conditions, but there is no good scientific evidence to support ...Overall, cats that received Solensia did better than those that didn't receive the drug. The most common side effects seen in cats treated with Solensia included vomiting, diarrhea,... self unloading round bale trailer 2021/09/04 ... No adverse effects were reported after FMT. ... was to evaluate the effect of frunevetmab on the functional immune response in naïve cats.The root bark is used to make medicine. People use Jamaican dogwood for anxiety, sleep problems, nerve pain, migraine, and other conditions, but there is no good scientific evidence to support ...The most common side effects seen in cats include vomiting, diarrhea, injection site pain, scabbing on the head and neck, dermatitis and pruritus (itchy ...The most common side effects seen in cats include vomiting, diarrhea, injection site pain, scabbing on the head and neck, dermatitis and pruritus (itchy skin). [2] Frunevetmab is a cat-specific monoclonal antibody (a type of protein) designed to recognize and attach to a protein called nerve growth factor (NGF) that is involved in the ...Jan 20, 2023 · Some potential side effects include: fever, chills, and other flu-like symptoms. hot flashes. joint pain. leg cramps. sweating. swelling in the hands or feet. infection. Studies have also linked ... gu10 bulbs tesco 2022/02/07 ... What are the known side effects of Solensia? · Vomiting · Diarrhea · Pain at the injection site · Scabbing on the head and neck · Irritated skin.Side effects. NSAIDs are the most common treatment, but there are: ... Frunevetmab. THE FIRST AND ONLY MONTHLY INJECTABLE ANTIBODY. solar battery storage companies 2022/01/13 ... The most common adverse effects seen in cats treated with frunevetmab injection included vomiting, diarrhea, injection site pain, ...Some potential side effects include: fever, chills, and other flu-like symptoms. hot flashes. joint pain. leg cramps. sweating. swelling in the hands or feet. infection. Studies have also linked ...Overall, frunevetmab administration resulted in a very low incidence of treatment-emergent immunogenicity with no safety findings and minimal effect on drug exposure and efficacy. View Show abstractWhy is Solensia authorised in the EU? The main study showed that Solensia was effective at reducing pain in cats with osteoarthritis, and the side effects are ... g1 test brampton (frunevetmab) in the treatment of DJD-associated pain. 25,26 Despite considerable advances over the last 15 years in our understanding of how to measure chronic pain in cats,27 a profound placebo effect (up to 80%) is described in clinical chronic pain trials using subjective owner assessment that trends higher with longer duration studies.28Methadone comes as a tablet, a dispersible (can be dissolved in liquid) tablet, a solution (liquid), and a concentrated solution to take by mouth. When methadone is used to relieve pain, it may be taken every 8 to 12 hours. If you take methadone as part of a treatment program, your doctor will prescribe the dosing schedule that is best for you.Recent work has shown promise for a feline-specific anti-nerve growth factor monoclonal antibody (frunevetmab) to deliver safe and effective pain management. Our objectives were to evaluate the efficacy and safety of frunevetmab administered twice using two administration routes (subcutaneous and intravenous) compared to placebo.2022/01/13 ... The most common adverse effects seen in cats treated with frunevetmab injection included vomiting, diarrhea, injection site pain, ... bmw software update Some potential side effects include: fever, chills, and other flu-like symptoms. hot flashes. joint pain. leg cramps. sweating. swelling in the hands or feet. infection. Studies have also linked ...Contra-indications, warnings, etc. Do not use in cases of hypersensitivity to the active substance or to any of the excipients. Do not use in animals under 12 months and/or under 2.5 kg body weight. Do not use in animals intended for breeding. Do not use in pregnant or lactating animals. Continuation of treatment should be based on the ... The side effects of NGF inhibitors have been known for over a decade. The FDA slowed the development of NGF inhibitors in 2010 because of concerns they make … doberman pinscher puppies for sale near london In a press release announcing the approval of Solensia for cats, the FDA makes no mention of RPOA in its list of side effects, which includes vomiting, diarrhea, injection site. 2x 1ml vials. Indication. Solensia is a once-a-month subcutaneous injection which is long-acting medication for cats with osteoarthritis pain. Contraindications. kamloops urgent care clinic Onset of effect Frunevetmab was demonstrated to provide analgesic effect within 6 days in an acute inflammatory pain laboratory model. Pharmacokinetics In a 6-month laboratory study of healthy, adult cats administered frunevetmab every 28 days at doses ranging from 2.8-14 mg/kg, AUC and Cmax increased slightly less than in proportion to dose. sonic .exe Solensia (frunevetmab) is an injectable monoclonal antibody made by Zoetis that targets nerve growth factor (NGF), a protein that increases in animals and humans due to injury, inflammation or pain. Solensia is designed to bind to NGF and inhibit pain signals from reaching the brain. Osteoarthritis (OA) is a progressive joint disorder that ...Many treatments and medical procedures can cause side effects, which can be positive but more often are unwanted. Causes of adverse effects include drug interactions, reactions to specific drug ...frunevetmab [usan] sources: common name english frunevetmab [inn] sources: common name english immunoglobulin g1, anti-(mus musculus nerve growth factor) (felis catus-rattus norvegicus monoclonal nv-02 heavy chain), disulfide with felis catus-rattus …Recent work has shown promise for a feline-specific anti-nerve growth factor monoclonal antibody (frunevetmab) to deliver safe and effective pain management. Our objectives were to evaluate the efficacy and safety of frunevetmab administered twice using two administration routes (subcutaneous and intravenous) compared to placebo. properties for sale on sandy bay canvey island